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In the “one more thing to worry about” category comes a surprise from a multi-center study just published in JAMA, which postulates that the use of sildenafil (Viagra) may increase the risk of malignant melanoma. Unlike many of the junk studies we routinely lambaste here, this one is well run and also has a biologically plausible mechanism to explain the findings. It is also a prospective study — one planned in advance to explore a theory — rather than a retrospective study, (often called data dredging) where data from past studies are analyzed to find some kind of correlation between two events. The former is almost always more scientifically valid compared to the latter. Lead author Wen-Qing Li, PhD of the Department of Dermatology, Brigham and Women’s Hospital at Harvard Medical School and co-workers studied almost 26,000 men over a ten year period. During this time, 142 cases of malignant melanoma were confirmed. Men who had taken sildenafil were found to have twice the incidence of melanoma than those who did not.

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